GLENDALE, Ariz. -- The Arizona Cardinals can score, especially at home.
The Buffalo Bills, without their starting quarterback, couldn't even stay close.
A fierce hit by Arizona's Adrian Wilson on the third play of the game sent second-year quarterback Trent Edwards to the locker room with a concussion and the Cardinals went on to manhandle the previously unbeaten Bills 41-17 on Sunday.
The Cardinals, who host Dallas next weekend, have played two home games this season, outscoring Miami and Buffalo by a combined 72-17. On the road, they're 1-2, including a 56-35 loss to the New York Jets the previous weekend.
Gaining redemption was a major motivation for the Cardinals.
"I know our guys were upset because all guys in the NFL are prideful," Arizona coach Ken Whisenhunt said, "and when you have a game like that, it really drives the point home."
Kurt Warner bounced back from an awful weekend at the Meadowlands to pick apart the Bills' defense with short passes, completing 33 of 42 for 250 yards and a pair of touchdowns to Larry Fitzgerald, with no interceptions. Nine Arizona receivers had catches. The Cardinals had no lost fumbles or interceptions.
"We're a tough team to beat when we don't turn the ball over," said Whisenhunt, whose team had seven turnovers against the Jets.
Buffalo committed four turnovers, resulting in 17 points for Arizona.
"When you play a team like this, there won't be any miracles," Losman said. "If you turn over the ball as many times as we did, and the penalties, they take advantage of that. Good teams will."
Warner threw three interceptions and fumbled the ball away three times against the Jets, so he spent the week hanging onto the football around the house.
"I was actually chasing my kids around and I had two hands on the football," the father of seven said, "or they were chasing me around trying to simulate the Buffalo Bills."
Rookie Tim Hightower had touchdown runs of 17 and 2 yards for the Cardinals, who now stand alone atop the NFC West. The Cardinals (3-2), without standout receiver Anquan Boldin, amassed 373 yards against what had been one of the stingier defenses in the league.
Buffalo had rallied in the fourth quarter to win its last three. The Bills, playing without cornerback Terrence McGee (sprained knee), were down 31-17 after three in this one, and it only got worse from there.
Coach Dick Jauron painted as positive a picture on the loss as he could.
"I'd much rather go into the bye week 5-0 than 4-1," he said, "but I'm willing to bet there's not a lot of people in this room that thought we'd be 4-1."
Losman, who wanted an offseason trade after losing his job to Edwards, was 15-of-21 for 220 yards, most of them on an 87-yard touchdown pass to Lee Evans. He was sacked five times.
"I try to mentally prepare every game like I'm going to go in," Losman said. "Today, I was put to that test -- quite early -- which is unexpected. But that's my job right now."
With Boldin out as a result of the vicious helmet-to-helmet hit by the Jets' Eric Smith, his replacement Steve Breaston caught seven passes for 77 yards.
"I went up to Steve during the game and just told him every game I'm gaining more confidence in him," Warner said. "I'm feeling better that when we get into those crucial situations, I'll throw the ball to him."
Fitzgerald had seven catches for 52 yards and rookie Early Doucet, in his pro debut, caught six for 42 yards.
Very early, it looked to be a long day in the desert for the Bills.
Wilson blitzed untouched and leveled Edwards, slamming the second-year quarterback onto his back. Edwards lay on the ground for several minutes before being helped to the sidelines.
"I don't think it was helmet-to-helmet but I've only seen one replay on the big board," Jauron said. "There are other things involved in any hit on a quarterback so we'll see where that one goes."
Wilson immediately signaled to the Buffalo sideline that Edwards was hurt.
"I know the situation that happened with Anquan last week," Wilson said, "so it was just a scary situation whenever you see a guy just laying there and not moving."
Notes: Arizona is 8-2 at home since Whisenhunt was hired. ... Turnovers set up the Cardinals' 10 fourth-quarter points. ... The Cardinals had 28 first downs, 19 in the first half, and a 121/2-minute advantage in time of possession. ... Buffalo entered the game allowing teams to convert on third downs an NFL-best 19 percent of the time. Arizona converted 9-of-13, 6-of-6 in the first half.
(Copyright 2008 by The Associated Press. All Rights Reserved.)
